![]() “We discovered that individuals who developed postvaccine myocarditis uniquely exhibit elevated levels of free spike protein in circulation, unbound by antispike antibodies, which appear to correlate with cardiac troponin T levels and innate immune activation with cytokine release,” they explain, adding, “Although these findings might provide insight into the immunophenotype of vaccine-related myocarditis, they do not alter the risk-benefit ratio strongly favoring vaccination to protect against severe COVID-19-related complications.” Yonker, MD (Massachusetts General Hospital, Boston), and colleagues turned to immunoprofiling as a way to better understand the underlying mechanisms. ![]() Prior studies have provided insight into the key clinical features of myocarditis cases, rare but real, seen with Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccines.įor their paper, published online in Circulation, Lael M. Levels of the antigen were unusually high among those with myocarditis. Instead, the complication seems related to how some individuals process spike protein, produced by the body using the vaccine’s mRNA as a template. ![]() Myocarditis that arises after receipt of an mRNA-based COVID-19 vaccine among adolescents and young adults does not appear to result from a heightened overall immune response or from autoantibodies, new data suggest. ![]()
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